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Edward E. Barnard photographic atlas of the Milky Way is a classic work.
Sherburne W. Burnham measured orbits of stars around each other.
Otto Struve made major contributions in the field of stellar spectroscopy.
Bengt Stromgren added greatly to our understanding of interstellar gas clouds
Gerard Kuiper discovered carbon dioxide in the atmosphere of Mars; he also discovered the fifth moon of Uranus, and the second moon of Neptune.
W. Albert Hiltner discovered that interstellar dust particles cause a slight polarization of starlight.
Subrahmanyan Chandrasekhar, "The Chandrasekhar Limit". He won the Nobel Prize in Physics in 1983 for his theoretical studies of the physical processes concerning the structure and evolution of stars.
William W. Morgan established precise classification systems for the spectra of stars and the forms of galaxies., Morgan deduced the spiral nature of the Milky Way Galaxy.
George Ellery Hale invented a spectroheliograph when he was a student at MIT, before Yerkes Observatory even existed. Hale brought the spectroheliograph with him when he came to Yerkes.
Frank Schlesinger, developed the techniques used here and everywhere else for fundamental photographic measurement of stellar distances (parallax).
The Astrophysical Journal was founded at Yerkes by Hale and James Keeler in 1895, and it is even still an important journal.
See Also
Yerkes Observatory Photo Essay